Personalized Optimization of MNETs-Lu177 Therapy (POPEYE)

The POPEYE project uses advanced computational tools for the optimization of midgut neuroendocrine tumors (MNETs) treatment, towards the personalization of 177Lu therapeutic protocols. MNETs constitute the largest group of gastrointestinal NETs and they are the second most-common small bowel malignancy. Establishing prognosis and guiding patients about the most appropriate course of therapy are both challenging. An interdisciplinary approach exploits established tools and novel developments to increase the early, effective diagnosis and the efficacy of 177Lu radionuclide therapy. MC simulations incorporating ML techniques serve as gold standard and allows to estimate dosimetry on personalized treatment protocols. A well-established management & dissemination plan in combination with an extensive research on economic, ethical, legal and social aspects will allow to achieve POPEYEs final goal; the clinical evaluation and exploitation of the proposed software & hardware tools, as a support guidance to the clinicians, to assess personalized MNETS diagnosis and therapy protocols.

No additional funding sources recorded.