Chiral Iminophosphorane catalyzed Rearrangement Reactions

Rearrangement reactions are an effective way to synthesize small organic molecules with high atom economy. However, performing such reactions in an enantioselective manner is a challenging task and usually requires careful optimization of reaction conditions. During the abroad phase of this project, we plan to use chiral, bifunctional iminophosphoranes to control configuration of reaction products of these rearrangements. This approach will allow for the synthesis of important chiral target structures, such as alcohols, thiols, amines and epoxides. Those molecules are not only important in more complex syntheses but also key building blocks in the pharmaceutical sector. Moreover, during the return phase of this project, we plan to develop novel superbasic catalysts which do not only have a basic site but also a chalcogen bond donor. Such catalysts have not been known up to date and can potentially broaden the application areas of superbases in stereoselective synthesis.

No additional funding sources recorded.