Mathematical Modeling of Bone Engineering (MAMBOing)

The project aims at introducing and validating a new model describing bone engineering (BE) after traumas, osteoporosis, or tumors. Such a model appears to be the first capable of simultaneously taking into consideration both the bulk and the surface mechanisms underlying the bone regeneration, which is indeed crucial in order to characterize bone morphologies and to study their mechanical properties especially when polymeric scaffold are employed to enhance the bone growth. The approach consists in transferring techniques developed for the SDRI model in the context of Materials Science and to justify the model for the BE setting by p hase-field approximations. The new model represents a tool to ultimately improve surgical procedures by, e.g., easing the production of bone scaffolds, and the research risks seem to be manageable by introducing proper specific model modifications.

No additional funding sources recorded.