Cancer evolution and identification of relapse-initiating cells (CEVIR)

Cancer is an evolutionary disease, and cancer cells are constantly changing in response to se- lection pressures imposed by the environment and by treatment. The CEVIR project will study relapse-initiating cells using genomics and epigenomics technology. The resulting data will be used to reconstruct the evolutionary processes in lung cancers using computational methods, with the goal of developing blood-based monitoring assays for identifying the earli- est signs of cancer relapse. Within the CEVIR project, the lab of Christoph Bock at the CeMM Research Center for Molecular Medicine (http://epigenomics.cemm.oeaw.ac.at) will perform DNA methylation sequencing on cell-free DNA and single cells, and they will con- tribute their expertise with bioinformatic analysis of next generation sequencing data.

No additional funding sources recorded.