Multi-Omics Analyse des Antikörpermangelsyndroms (i-PAD)

The human immune system controls how we respond to infections and other diseases. How- ever, its functioning differs substantially between individuals. Certain people have mild or severe immune defects, which makes them prone to infections, autoimmunity and cancer. Some of these immunodeficiencies are monogenetic and relatively well understood. But in many cases the molecular cause is entirely unknown, which makes these rare diseases diffi- cult to diagnose and treat. In this project, we will use cutting-edge multi-omics profiling and integrative bioinformatic analysis to dissect the molecular pathways underlying common var- iable immunodeficiency, an archetypical rare primary antibody deficiency (PAD) where im- paired B cell function causes recurrent infections. Within the i-PAD project, the lab of Chris- toph Bock at the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (http://rarediseases.at/) will focus on high-throughput profiling of chromatin accessibility and on the integrative bioinformatic analysis of all datasets.